The sensitivity, specificity and optimal cut-off values were 73.9 %, 59.7 % and 14.1 µmol –1, respectively. The sensitivity, specificity and optimal cut-off values were 95.7 %, 35.1 % and 1.14 mmol l –1, respectively. ROC curve analysis showed that the area under the curve (AUC) of TG was 0.690 (95 % CI 0.577–0.789, P=0.002). Triglyceride (TG) and homocysteine (Hcy) levels were identified as independent risk factors for SIBO in patients with AIS using multivariate logistic regression analysis ( P<0.005). Of the 80 consecutive patients with AIS, 23 (28.8 %) tested positive for SIBO. The independent risk factors and predictive value of SIBO in AIS patients were determined using multivariate logistic regression and receiver operating characteristic (ROC) curve analyses. The baseline characteristics and clinical biochemical indicators of the patients were compared between the two groups. Patients were divided into SIBO-positive and SIBO-negative groups according to the presence or absence of SIBO, respectively. Eighty patients tested for SIBO using the lactulose hydrogen–methane breath test were evaluated. This study aimed to investigate the prevalence and risk factors of SIBO in patients with AIS Given that the prevalence of SIBO and its risk factors in patients with AIS remain to be studied, there is a need to investigate them.Īim. Exploring the prevalence of SIBO and its associated risk factors will provide a clinical basis for the association between intestinal flora and AIS. Recently, the lactose hydrogen–methane breath test has emerged as a non-invasive and economical method for the detection of SIBO in AIS patients. The intestinal flora has become a promising new target in acute ischaemic stroke (AIS), and small intestinal bacterial overgrowth (SIBO) is a common pathological condition of the intestinal flora.
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